Animal and cellular models of human disease.
نویسندگان
چکیده
In this eighteenth (2016) Annual Review Issue of The Journal of Pathology, we present a collection of 19 invited review articles that cover different aspects of cellular and animal models of disease. These include genetically-engineered models, chemically-induced models, naturally-occurring models, and combinations thereof, with the focus on recent methodological and conceptual developments across a wide range of human diseases.
منابع مشابه
Stem Cells Application in Modeling of Human Genetic Diseases
The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...
متن کاملExperimental Models of Absence Epilepsy; A Review Article
Background: Absence epilepsy is a brief non-convulsive seizure that associated with sudden abrupt in consciousness. Because of the unpredictable occurrence of absence seizures and ethic limitation of human investigation on the pathogenesis and drug assessment led to the tendency to animal models. The aim of this paper is reviewing the advantages and disadvantages of several animal models of non...
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Liver flukes-induced pathological changes in liver parenchyma and biliary passages are so severe that, in some cases, may cause total physiologic dysfunction. The human disease is endemic to some parts of the country, and there were two vast epidemics of the human fascioliasis in Gilan province, northern most part of the country. According to WHO reports , the human disease is prevalent in Gila...
متن کاملA Review of Animal Models of Alzheimer\'s Disease: a brief insight to Pharmacologic and genetic models
Alzheimer's disease (AD) is the most common form of neurodegenerative disorders. Memory loss in an alert person and impairment in the function of language, attention, perception, judgment or problem solving can occur in patients with AD. However, there are some medications in order to delay the debilitating aspects of the disease; but unfortunately, scientists could not found approaches to cure...
متن کاملThe role of glia in neurological disease
Glial cells form a network in the central nervous system to support neurons and interact with them. The glia consist essentially of astrocytes that help with the nutrition of neurons and react in some cases of injury, oligodendrocytes that produce myelin, and microglia that are derived from the haemopoietic system and are concerned with the immunological defense of the nervous system. Experimen...
متن کاملP-111: An Attempt to Facilitate the Production of Transgenic Mouse As A Model for Gene Therapy of Gaucher Disease
Background: Gaucher disease is an autosomal recessive inherited lysosomal storage disorder that affects many of the body's organs and tissues by defective function of the catabolic enzyme β-glucocerebrosidase. Gene therapy is one of the efficient ways for treatment of this disease. Due to the lack of appropriate animal models, in the field of gene therapy little progress has been done.Mate...
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ورودعنوان ژورنال:
- The Journal of pathology
دوره 238 2 شماره
صفحات -
تاریخ انتشار 2016